Metabolic Fate of Dorzolamide, a New Carbonic Anhydrase Inhibitor. (I): Absorption, Distribution, Metabolism and Excretion of (14C)Dorzolamide after Single Administration to Rats.

Absorption, distribution, metabolism, and excretion of donepezil (Aricept) after a single oral administration to Rat.

Donepezil hydrochloride (Aricept) is a drug for the treatment of Alzheimer's disease. The absorption, distribution, metabolism, and excretion of donepezil were investigated in male Sprague-Dawley rats after a single oral administration. Orally administered (14)C-labeled donepezil was absorbed rapidly. The plasma level of unchanged donepezil declined more rapidly than that of radioactivity, and ...

Absorption, Distribution, and Excretion of 14C-APX001 after Single-Dose Administration to Rats and Monkeys

2135 Systemic pharmacokinetics and carbonic anhydrase inhibition of dorzolamide

fir-pose: Dorzolamide @ORE) is a topical carbonic anhydrase (CA) inhibitor that is approved for treatment of open-angle glauccma and ocular hypertension. DORE exerts its effects directly in the eye at substantially lower doses and therefore with less systemic exposure than oral CA inhibitors To evaluate DORZ's potential for systemic CA inhibition, maximum systemic exposure was simulated through...

Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats.

Recent reports have demonstrated various cardiovascular and neurological benefits associated with the consumption of foods rich in anthocyanidins. However, information regarding absorption, metabolism, and especially, tissue distribution are only beginning to accumulate. In the present study, we investigated the occurrence and the kinetics of various circulating pelargonidin metabolites, and we...

Absorption and excretion of metronidazole. I. Serum concentration and urinary excretion after oral administration.

Metronidazole (200 mg. three times daily for 7 days) cures approximately 90 per cent. of patients infested with Trichomonas vaginalis (Rodin, King, Nicol, and Barrow, 1960). This paper describes the first stage of an investigation designed to determine, in the first instance, the general absorption and excretion pattern of the drug and, secondly, the cause of failure in the remaining 10 per cen...